Five people are dead and “likely more” have lost their lives, while at least 130,000 people are under evacuation orders and warnings.
US states are sending in firefighting resources to bolster efforts on the ground.
There are multiple active wildfires burning including the Palisades fire, the Eaton fire, the Hurst fire and the Woodley fire.
Firefighters are facing enormous challenges across the grounds battling hurricane-force winds accompanied by drought conditions.
Tens of thousands of people have been told by authorities to evacuate their homes because of the multiple fires burning in the Los Angeles region.
The most recent mandatory evacuations orders came on Wednesday evening (Thursday afternoon Australian time) related to the Sunset fire, a new fire in the Hollywood Hills.
That order was in place for Laurel Canyon Boulevard on the west to Mulholland Drive, with others in nearby areas warned to be ready to leave.
Mandatory evacuation orders also remained in place near the Palisades fire west of Los Angeles, including parts of Santa Monica.
People have also been told to leave their homes in the San Fernando Valley near the Hurst fire.
Others were told to leave their residences in parts of Altadena because of the Eaton fire.
A fast-moving fire broke out in the Hollywood Hills is threatening one of Los Angeles’ most iconic spots.
The Sunset Fire was burning near the Hollywood Bowl and about a kilometre from the Hollywood Walk of Fame.
The streets around Grauman’s Chinese Theatre and Madame Tussauds were packed with stop-and-go traffic as sirens blared and low-flying helicopters soared by on their way to dump water on the flames.
People toting suitcases left hotels on foot, while some onlookers walked towards the flames, recording the fire on their phones.